Brucellosis often takes a long, recurrent course, delayed until 1-2-3 years and, in rare cases, more. There are several classifications of brucellosis, based on which it is practically important to distinguish following forms: 1) The acute form of generalization or primary phase of infection without focal lesions, the duration of 2-3 months. The main symptoms of this form of fever, chills, sweating, lack of typhoid status hypotension, bradycardia often, poliadenopatiya, an increase in the spleen and liver. In the blood was leukopenia with limfomonotsitozom. Reaction Wright Heddlsona – Kaytmchzovoy and Burne vnutrnkozhnaya test positive with the 12-15th day disease.
2) a latent form, or phase, during which time no complaints and objective data, talking about the disease can be identified. 3) Subchronic form or phase of the localization of recurrent generalization. In patients with newly repeated symptoms of an acute process with the development of various focal lesions – especially on the part of the musculoskeletal system. Liver and spleen were enlarged and sealed. In the hemogram indicated leukopenia, neutropenia, lymphocytosis, normal ESR. The duration of this form of the disease is 2-3 months. 4) Chronic form: a) with relapsed and b) with persistent localized lesions. There are marked pain, the presence of persistent focal lesions may relapse, the temperature is normal or low-grade, accompanied by a slight chilling and sweating.
Enlarged spleen and liver is relatively rare. The total duration of the disease can be 2-5 years. Diagnosis. Recognition of brucellosis is based on epidemiological data, the analysis of clinical symptoms that develop in a strict sequence, is taken into account the shape and phase of illness, and the results laboratory studies. Important methods of diagnosis of brucellosis in humans are currently the following laboratory studies 1) The bacteriological examination of blood Pull the pathogen (blood culture, obtaining mielokultury). Because of the need to have special conditions and the duration of the laboratory bacteriological studies (3-4 weeks), this method is not widely applied.